Facilitating Endometrial Receptivity to Improve Pregnancy Outcomes

Grant number: 1120689 | Funding period: 2018 - 2021

Completed

Abstract

The womb prepares itself in each menstrual cycle for pregnancy and the implantation of an embryo. In some women, the endometrium may not prepare itself adequately and this can lead to infertility. We have identified small RNA that may be useful in predicting which women are not adequately prepared for implantation and may be used to develop treatments for infertile women, for which there are currently no treatments.

Related publications (10)

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WD-repeat containing protein-61 regulates endometrial epithelial cell adhesion indicating an important role in receptivity

P Downing, M Howe, M Sacco, LL Santos, E Menkhorst, WT Teh, T Lucky, W Zhou, E Dimitriadis

2024-11-01

Endometrial receptivity is crucial for successful embryo implantation during early pregnancy. The human endometrium undergoes remo..

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Dysregulated miR-124-3p in endometrial epithelial cells reduces endometrial receptivity by altering polarity and adhesion

W Zhou, M Van Sinderen, K Rainczuk, E Menkhorst, K Sorby, T Osianlis, M Pangestu, L Santos, L Rombauts, A Rosello-Diez, E Dimitriadis

2024-10-08

The endometrium undergoes substantial remodeling in each menstrual cycle to become receptive to an implanting embryo. Abnormal end..

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The human periconceptional maternal-embryonic space in health and disease

Inmaculada Moreno, Antonio Capalbo, Aymara Mas, Tamara Garrido-Gomez, Beatriz Roson, Maurizio Poli, Eva Dimitriadis, Xavier Santamaria, Felipe Vilella, Carlos Simon

2023-01-01

Pregnancy is established during the periconceptional period as a continuum beginning with blastocyst attachment to the endometrial..

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Infertile human endometrial organoid apical protein secretions are dysregulated and impair trophoblast progenitor cell adhesion

W Zhou, S Barton, J Cui, LL Santos, G Yang, C Stern, V Kieu, WT Teh, C Ang, T Lucky, J Sgroi, L Ye, E Dimitriadis

2022-12-14

Introduction: Embryo implantation failure leads to infertility. As an important approach to regulate implantation, endometrial epi..

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Jagged1 regulates endometrial receptivity in both humans and mice

W Zhou, E Menkhorst, E Dimitriadis

2021-08-01

The human endometrium undergoes cycle-dependent changes and is only receptive to an implanting blastocyst within a narrow window o..

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MAML1: a coregulator that alters endometrial epithelial cell adhesive capacity.

Sadaf Zafir, Wei Zhou, Ellen Menkhorst, Leilani Santos, Evdokia Dimitriadis

2021-03-27

BACKGROUND: Abnormalities in endometrial receptivity has been identified as a major barrier to successful embryo implantation. End..

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Alterations in Epithelial Cell Polarity During Endometrial Receptivity: A Systematic Review

S Whitby, W Zhou, E Dimitriadis

2020-10-27

Background: Abnormal endometrial receptivity is one of the major causes of embryo implantation failure and infertility. The plasma..

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Secreted MicroRNA to Predict Embryo Implantation Outcome: From Research to Clinical Diagnostic Application

W Zhou, E Dimitriadis

2020-09-22

Embryo implantation failure is considered a leading cause of infertility and a significant bottleneck for in vitro fertilization (..

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Characterization of the role for cadherin 6 in the regulation of human endometrial receptivity

W Zhou, L Santos, E Dimitriadis

2020-06-29

Background: The endometrial luminal epithelium is the first point of attachment of embryos during implantation. Failure of embryos..

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miR-29c overexpression and COL4A1 downregulation in infertile human endometrium reduces endometrial epithelial cell adhesive capacity in vitro implying roles in receptivity

M Griffiths, M Van Sinderen, K Rainczuk, E Dimitriadis

2019-12-01

The endometrium is a highly complex tissue that is vulnerable to subtle gene expression changes and is the first point of contact ..

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